Lawrence Joseph
Bayesian statistics


Please Note: Prof. Joseph has retired.
These pages are left up in case they prove
useful, but the pages and software will
no longer be updated. All material and
software is "as is" with no guarantees
of functionality or correctness.
Allergy and immunology Asthma Cardiology Gastroenterology Osteoporosis Quality of Life Rheumatology Other
Complete CV
Research interests
Courses taught
Previous courses taught
EPIB-607 Principles of Inferential Statistics in Medicine
EPIB-613 Introduction to Statistical Software
EPIB-621 Data Analysis in the Health Sciences
EPIB-651 Bayesian Analysis in Medicine
EPIB-668 Introduction to Bayesian Analysis in the Health Sciences
EPIB-669 Intermediate Bayesian Analysis for the Health Sciences
EPIB-675 Bayesian Analysis in the Health Sciences
EPIB-682 Introduction to Bayesian Analysis in the Health Sciences
EPIB-683 Intermediate Bayesian Analysis for the Health Sciences
Publications
Methodological publications
Bayesian Sample Size
Change-point methods and applications
Diagnostic testing
Meta analysis
Other topics
Medical publications
Allergy and immunology
Asthma
Cardiology
Gastroenterology
Osteoporosis
Quality of Life
Rheumatology
Other
Book
Bayesian software
Bayesian Sample Size
Change-point methods and applications
Diagnostic testing
Diagnostic testing in Genetics
Links
Tsoukas A, Pineau C, Joseph L, Buckeridge D, Bélisle P, Bernatsky S.
Clinically apparent arterial thrombosis in persons with systemic vasculitis
International Journal of Rheumatology 2017;2017:1-6
Bernatsky S, Smargiassi A, Joseph L, Awadalla P, Colmegna I, Hudson M, Fritzler M.
Industrial air emissions, and proximity to major industrial emitters, are associated with anti-citrullinated protein antibodies.
Environmental Research 2017;157:60-63
Bernatsky S, Ramsey-Goldman R, Petri M, Urowitz M, Gladman D, Fortin P, Ginzler E, Romero-Diaz J, Peschken C, Jacobsen S, Hanly J, Gordon C, Nived O, Yelin E, Isenberg D, Rahman A, Bae S, Joseph L, Witte T, Ruiz-Irastorza G, Aranow C, Kamen D, Sturfeldt G, Foulkes W, Hansen J, St. Pierre Y, Raymer P, Tessier-Cloutier B, Clarke A.
Breast cancer in systemic lupus
Lupus 2017;26(3):311-315
Labrecque J, Kyle R, Joseph L, Bernatsky S.
Health-selective migration among patients with rheumatoid arthritis in Quebec: a cohort study using administrative data
Rheumatology International 2016;36(9):1275-1279
Bourré-Tessier J, Urowitz M, Clarke A, Bernatsky S, Krantz M, Huynh T, Joseph L, Bélisle P, Ibanez D, Pineau C.
Electrocardiographic findings in systemic lupus erythematosus: Data from an international inception cohort
Arthritis Care and Research 2015;67(1):128-135
Barnabe C, Hemmelgarn B, Jones A, Peschken C, Voaklander D, Joseph L, Bernatsky S, Esdaile J, Marshall D.
Imbalance of prevalence and specialty care for osteoarthritis for First Nations people in Canada.
The Journal of Rheumatology 2015;42(2):323-328
Bernatsky S, Ramsey-Goldman R, Boivin JF, Joseph L Petri M, Zoma A, Manzi S, Urowitz MB, Gladman D, Fortin PR, Ginzler E, Yelin E, Bae S, Wallace D, Edworthy S, Jacobsen S, Gordon C, Dooley M, Peschken C, Hanly J, Alarcon G, Nived O, Ruiz-Irastorza G, Isenberg D, Rahman A, Witte T, Aranow C, Kamen D, Steinsson K, Askanase A, Barr S, Criswell LA, Sturfelt G, Patel N, Senécal J, Zummer M, Pope J, Ensworth S, El-Gabalawy H, McCarthy T, Dreyer L, Labrecque J, St Pierre Y, Sibley J, Clarke A.
Cancer risk factors in SLE: Multivariate regression analysis in 16,409 patients
Journal of Autoimmune Diseases and Rheumatology 2014;2:100-103
Bernatsky S, Clarke A, Labrecque J, von Scheven E, Schanberg L, Silverman E, Brunner H, Haines K, Cron R, O'Neil K, Oen K, Rosenberg A, Duffy C, Joseph L, Lee J, Kale M, Turnbull E, Ramsey-Goldman R.
Cancer risk in childhood-onset systemic lupus
Arthritis Research & Therapy 2013;15(6):R198
Bernatsky S, Ramsey-Goldman R, Labrecque J, Joseph L, Petri M, Zoma A, Manzi S, Urowitz M, Gladman D, Fortin P, Ginzler E, Yelin E, Bae1 S, Wallace D, Edworthy S, Jacobsen S, Gordon C, Dooley M, Peschken C, Hanly J, Alarcón G, Nived O, Ruiz-Irastorza G, Isenberg D, Rahman A, Witte T, Aranow C, Steinsson K, Barr S, Criswell L, Sturfelt G, Senécal J, Zummer M, Pope J, Ensworth S, El-Gabalawy H, McCarthy T, Dreyer L, Sibley J, St. Pierre Y, Clarke A.
Lymphoma risk in systemic lupus: Effects of disease activity versus treatment
Annals of Rheumatic Diseases 2013;73(1):138-142
Bourré-Tessier J, Peschken CA, Bernatsky S, Joseph L, Clarke AE, Fortin PR, Hitchon C, Mittoo S, Smith D, Zummer M, Pope J, Tucker L, Hudson M, Arbillaga H, Esdaile J, Carette S, Silverman E, Chédeville G, Huber AM, Bélisle P, Pineau CA.
Association of smoking with cutaneous manifestations in systemic lupus erythematosus
Arthritis Care and Research 2013;65(8):1275-1280
Bernatsky S, Ramsey-Goldman R, Labrecque J, Joseph L, Petri M, Zoma A, Manzi S, Urowitz M, Gladman D, Fortin P, Ginzler E, Yelin E, Bae1 S, Wallace D, Edworthy S, Barr S, Jacobsen S, Gordon C, Dooley M, Peschken C, Hanly J, Alarcón G, Nived O, Ruiz-Irastorza G, Isenberg D, Rahman A, Witte T, Aranow C, Steinsson K, Sturfelt G, Senécal J, Zummer M, Pope J, Ensworth S, l-Gabalawy H, McCarthy T, DreyerL, Sibley J, Pierre Y, Clarke A.
Cancer risk in systemic lupus: An updated international multi-centre cohort study
Journal of Autoimmunity 2013;42:130-135
Jönsen A, Clarke A, Joseph L, Bélisle P, Bengtsson A, Bernatsky S, Nived O, Sturfelt G, Pineau C.
Charlson co-morbidity index is associated with mortality in systemic lupus erythematosus
Arthritis Care and Research 2011;63(9):1233-1237
Bourré-Tessier J, Huynh T, Clarke A, Bernatsky S, Joseph L, Bélisle P, Pineau.
Features associated with cardiac abnormalities in systemic lupus erythematosus
Lupus 2011;20(14):1518-1525
Bourré-Tessier J, Clarke A, Huynh T, Bernatsky S, Joseph L, Bélisle P, Pineau C.
Prolonged corrected QT interval in Anti-Ro/SSA positive adults with systemic lupus erythematosus
Arthritis Care and Research 2011;63(7):1031-1037
Bernatsky S, Joseph L, Pineau C, Bélisle P, Boivin J, Banerjee D, Clarke A.
Estimating the prevalence of polymyositis and dermatomyositis from administrative data: Age, sex and regional differences
Annals of the Rheumatic Diseases 2009;68:1192-1196
Hazel E, Bernatsky S, Da Costa D, Dasgupta K, Clarke A, Joseph L, St-Pierre Y, Pineau C.
Application of a nomogram for exercise capacity in women with systemic lupus erythematosus
Clinical Rheumatology 2009;28(6):719-722
Appenzeller S, Clarke A, Panopalis P, Joseph L, St-Pierre Y, Li T.
The relationship between renal activity and quality of life in systemic lupus erythematosus
The Journal of Rheumatology 2009;36(5):947-952
Neville C, Rauch J, Kassis J, Solymoss S, Joseph L, Bélisle P, Subang R, Fortin P.
Antiphospholipid antibodies predict imminent vascular events independently from other risk factors in a prospective cohort
Thrombosis and Haemostasis 2009;101(1):100-107
Bernatsky S, Boivin J, Joseph L, Urowitz M, Gladman D, Ginzler E, Gordon C, Fortin P, Bae S, Barr S, Isenberg D, Rahman A, Petri M, Alarcon G, Aranow C, Dooley M, Rajan R, Senecal J, Zummer M, Manzi S, Edworthy S, Ramsey-Goldman R, Clarke A.
The relationship between cancer and medication exposures in systemic lupus erythematosus: A case-cohort study
Annals of Rheumatic Diseases 2008;67(1):74-79
Panopalis P, Petri M, Manzi S, Isenberg D, Gordon C, Senecal J, Penrod J, Joseph L, St-Pierre Y, Pineau C, Fortin P, Sutcliff N, Goulet J, Choquette D, Grodzicky T, Esdaile J, Clarke A.
The systemic lupus erythematosus tri-nation study: cumulative indirect costs
Arthritis Care and Research 2007;57(1):64-70
Bernatsky S, Ramsey-Goldman R, Isenberg D, Rahman A, Dooley M, Sibley J, Boivin J, Joseph L, Armitage J, Zoma A, Clarke A.
Hodgkin's lymphoma in systemic lupus erythematosus
Rheumatology 2007;46(5):830-832
Bernatsky S, Joseph L, Pineau C, Tamblyn R, Feldman D, Clarke A.
A population-based assessment of systemic lupus erythematosus incidence and prevalence: results and implications of using administrative data for epidemiologic studies
Rheumatology 2007;46(12):1814-1818
Bernatsky S, Boivin J, Joseph L, Manzi S, Ginzler E, Gladman A, Urowitz M, Fortin P, Petri M, Barr S, Gordon C, Bae S, Isenberg D, Zoma A, Aranow C, Dooley M, Nived O, Sturfelt G, Steinsson K, Alarcon G, Senécal J, Zummer M, Hanly J, Ensworth S, Pope J, Edworthy S, Rahman A, Sibley J, El-Gabalawy H, McCarthy T, St-Pierre Y, Ramsey-Goldman R, Clarke A.
Mortality in systemic lupus erythematosus
Arthritis and Rheumatism 2006;54(8):2550-2557
Neville C, Rauch J, Kassis J, Solymoss S, Joseph L, Bélisle P, Chang R, Fortin P.
The persistence of anticardiolipin antibodies is associated with the presence of lupus anticoagulant and anti-β2-glycoprotein I antibodies
Rheumatology 2006;45:1116-1120
Bernatsky S, Boivin J, Joseph L, Rajan R, Zoma A, Manzi S, Ginzler E, Urowitz M, Gladman D, Fortin P, Edworthy S, Barr S, Petri M, Gordon C, Bae S, Sibley J, Isenberg D, Rahman A, Aranow C, Dooley M, Steinsson K, Alarcon G, Senecal J, Zummer M, Nived O, Sturfeldt G, Hanly J, Pope J, Ensworth S, El-Gabalawy H, McCarthy T, St-Pierre Y, Ramsey-Goldman R, Clarke A.
An international cohort study of cancer in systemic lupus erythematosus (SLE)
Arthritis and Rheumatism 2005;52(5):1481-1490
Panopalis P, Petri M, Manzi S, Isenberg D, Gordon C, Senecal J, Penrod J, Joseph L, St-Pierre Y, Pineau C, Fortin P, Sutcliff N, Goulet J, Choquette D, Grodzicky T, Esdaile J, Clarke A.
The systemic lupus erythematosus tri-nation study: longitudinal changes in physical and mental well-being
Rheumatology 2005;44(6):751-755
Bernatsky S, Ramsey-Goldman R, Rajan R, Boivin J, Joseph L, Lachance S, Cournoyer D, Zoma A, Manzi S, Ginzler E, Urowitz M, Gladman D, Fortin P, Edworthy S, Barr S, Gordon C, Bae S, Sibley J, Steinsson K, Nived O, Sturfelt G, St-Pierre Y, Clarke A.
Non-Hodgkin's lymphoma in systemic lupus erythematosus
Annals of Rheumatic Diseases 2005;64(10):1507-1509
Bernatsky S, Boivin J, Joseph L, Manzi S, Ginzler E, Urowitz M, Gladman D, Fortin P, Gordon C, Barr S, Edworthy S, Bae SC, Petri M, Sibley J, Isenberg D, Rahman A, Steinsson K, Aranow C, Dooley M, Alarcon G, Hanly J, Sturfelt G, Nived O, Pope J, Ensworth S, Rajan R, El-Gabalawy H, McCarthy T, St-Pierre Y, Clarke A, Ramsey-Goldman R.
Race/ethnicity and cancer occurrence in systemic lupus erythematosus
Arthritis Care and Research 2005;53(5):781-784
Rahme R, Choquette D, Beaulieu M, Bessette L, Joseph L, Toubouti Y, LeLorier J.
Positive impact of a general practitioner educational intervention on osteoarthritis treatment in an elderly population
American Journal of Medicine 2005;118(11):1262-1270
Foltz V, St-Pierre Y, Rozenberg S, Rossignol M, Bourgeois P, Joseph L, Adam V, Penrod J, Clarke A, Fautrel B.
Use of complementary and alternative therapies by patients with self-reported chronic back pain: a nationwide survey in Canada
Joint Bone Spine 2005;72(6):571-577
Bernatsky S, Clarke A, Ramsey-Goldman R, Joseph L, Boivin J, Rajan R, Moore A, Leung M, Allen A, Gordon C.
The effect of hormonal exposures on breast cancer in systemic lupus erythematosus
Rheumatology 2004;43(8):1016-1024
Bernatsky S, Clarke A, Ramsey-Goldman R, Boivin J, Joseph L, Rajan R, Manzi S.
Breast cancer stage at time of detection in systemic lupus erythematosus
Lupus 2004;13(6):469-472
Kassis J, Neville C, Rauch J, Busque L, Chang E, Joseph L, Le Compte M, Subang R, Fortin P.
Antiphospholipid antibodies and thrombosis: Association with acquired activated protein C resistance in venous thrombosis and with hyperhomocysteinemia in arterial thrombosis
Thrombosis and Haemostasis 2004;92(6):1312-1319
Clarke A, Petri M, Manzi S, Isenberg D, Gordon C, Senecal J, Penrod J, Joseph L, St-Pierre Y, Fortin P, Sutcliffe N, Goulet J, Choquette D, Grodzicky T, Esdaile J.
The systemic lupus erythematosus tri-nation study: absence of a link between health resource use and health outcome
Rheumatology 2004;43(8):1016-1024
Bernatsky S, Ramsey-Goldman R, Gordon C, Joseph L, Boivin J-F, Rajan R, Allen A, Moore AD, Leung M-H, Clarke A.
Factors associated with abnormal pap results in systemic lupus erythematosus (SLE)
Rheumatology 2004;43(11):1386-1389
Bernatsky S, Ramsey-Goldman R, Boivin J, Joseph L, Moore A, Rajan R, Clarke A.
Do traditional Gail model risk factors account for increased breast cancer in women with lupus?
Journal of Rheumatology 2003;30(7):1505-1507
Neville C, Rauch J, Kassis J, Chang E, Joseph L, Le Compte M, Fortin P.
Thromboembolic risk in patients with high titre anticardiolipin and multiple antiphospholipid antibodies
Thrombosis and Haemostasis 2003;90(1):108-115
Bernatsky S, Pineau C, Joseph L, Clarke A.
Adherence to ophthalmologic monitoring for antimalarial toxicity in a lupus cohort
Journal of Rheumatology 2003;30(8):1756-1760
Fautrel B, Adam V, St-Pierre Y, Joseph L, Clarke A, Penrod J.
Use of complementary and alternative therapies by patients self-reporting arthritis or rheumatism: Results from a nationwide Canadian survey
Journal of Rheumatology 2002;29(11):2435-2441
Bernatsky S, Boivin J, Joseph L, St-Pierre Y, Moore A, Rajan R, Clarke A.
The prevalence of factors influencing cancer risk in women with lupus: social habits, reproductive issues, and obesity
Journal of Rheumatology 2002;29(12):2551-2554
Fortin P, Penrod J, Clarke A, St-Pierre Y, Joseph L, Bélisle P, Liang M, Ferland D, Phillips C, Mahomed N, Tanzer M, Sledge C, Fossel A, Katz J.
Timing for total joint replacement affects patient outcomes
Arthritis and Rheumatism 2002;46(12):3327-3330
Dobkin P, Dacosta D, Joseph L, Fortin P, Edworthy S, Beaulieu A, Smith D, Zummer M, Senecal J, Goulet J, Choquette D, Rich E, Ensworth S, Esdaile J, Cividino A, Gladman D, Barr S, St-Pierre Y, Clarke A.
Counterbalancing patient demands with evidence: Results from a pan-Canadian randomized clinical trial of brief supportive-expressive group psychotherapy for women with systemic lupus erythematosus
Annals of Behavioral Medicine 2002;24(2):88-99
Clarke A, St-Pierre Y, Joseph L, Penrod J, Sibley J, Haga M, Genant H.
Radiographic damage in rheumatoid arthritis correlates with functional disability but not direct medical costs
Journal of Rheumatology 2001;28(11):2416-24
Neville C, Clarke A, Joseph L, Bélisle P, Ferland D, Fortin P.
Learning from discordance in patient and physician global assessments of systemic lupus erythematosus disease activity
Journal of Rheumatology 2000;27:675-679
Tsakonas E, Fitzgerald A, Fitzcharles M, Cividino A, Carter Thorne J, M'Seffar A, Joseph L, Bombardier C, Esdaile J, and the HERA study Group.
The consequences of delayed therapy with second line agents in rheumatoid arthritis: A three year follow-up on the Hydroxychloroquine in early rheumatoid arthritis (HERA) study
Journal of Rheumatology 2000;27(3):623-629
Rahme E, Joseph L, Kong S, Watson D, LeLorier J.
Gastrointestinal healthcare resource use and costs associated with nonsteroidal antiinflamatory drugs versus acetaminophen: Retrospective cohort study of an elderly population
Arthritis and Rheumatism 2000;43(4):917-924
Moore A, Petri M, Manzi S, Isenberg D, Gordon C, Senecal J, St-Pierre Y, Joseph L, Penrod J, Fortin P, Sutcliff N, Goulet J, Choquette D, Grodzicky T, Esdaile J, Clarke A for the Tri-Nation study Group.
The use of alternative medical therapies in patients with systemic lupus erythematosis (SLE)
Arthritis and Rheumatism 2000;43(6):1410-1418
Clarke A, Levinton C, Joseph L, Penrod J, Zowall H, Sibley J, Grover S, Esdaile J.
Predicting the short term direct medical costs incurred by Canadian patients with rheumatoid arthritis
Journal of Rheumatology 1999;26(5):1068-1075
Moore A, Clarke A, Danoff D, Joseph L, Bélisle P, Neville C, Fortin P.
Can health utility measures be used in lupus research? A comparative validation and reliability study of 4 utility indices
Journal of Rheumatology 1999;26(6):1285-1290
Clarke A, Petri M, Manzi S, Isenberg D, Gordon C, Senecal J, St-Pierre Y, Joseph L, Penrod J, Fortin P, Sutcliffe N, Goulet J, Choquette D, Grodzicky T, Danoff D, Hamilton V, Esdaile J, and the Trination Study Group.
An international perspective on the well-being and health care costs for patients with systemic lupus erythematosus
Journal of Rheumatology 1999;26:1500-1511
Fortin P, Clarke A, Joseph L, Liang M, Tanzer M, Ferland D, Phillips C, Partridge A, Bélisle P, Fossel H, Mohamed N, Sledge C, Katz J.
Outcomes of total hip and knee replacement: preoperative functional status predicts outcomes at six months after surgery
Arthritis and Rheumatism 1999;42(8):1722-1728
Dobkin P, Fortin P, Joseph L, Esdaile J, Danoff D, Clarke A.
Psychosocial contributors to mental and physical health in patients with systemic lupus erythematosus
Arthritis Care and Research 1998;11(1):23-31
Mata S, Chhem R, Fortin P, Joseph L, Esdaile J.
Comprehensive radiologic evaluation of diffuse idiopathic skeletal hypertosis (DISH): development and inter-rater reliability of a scoring system
Seminars in Arthritis and Rheumatism 1998;28(2):88-96
Tsakonas E, Joseph L, Esdaile JM, Choquette D, Senecal JL, Cividino A, Danoff D, Osterland CK, Yeadon C, Smith CD.
A long-term study of hydroxychloroquine withdrawal on exacerbations in systemic lupus erythematosus
Lupus 1998;7:80-85
Mata S, Fortin P, Fitzcharles M, Starr M, Joseph L, Watts C, Gore B, Rosenberg E, Chhem R, Esdaile J.
A controlled study of diffuse idiopathic skeletal hyperostosis: clinical features and functional status
Medicine 1997;76(2):104-117
Esdaile JM, Abrahamowicz M, Joseph L, Li Y, MacKenzie T, Danoff D.
Laboratory tests as predictors of disease exacerbations in systemic lupus erythematosus - Why some tests fail
Arthritis and Rheumatism 1996;39:370-378
Esdaile J, Joseph L, Abrahamowicz M, Li Y, Danoff D, Clarke A.
Routine immunologic tests in systemic lupus erythematosus - Is there a need for more studies?
Journal of Rheumatology 1996;23(11):1891--1896
Mata S, Wolfe F, Joseph L, Esdaile JM.
Absence of an association of rheumatoid arthritis and diffuse idiopathic skeletal hyperostosis: A case-control study
Journal of Rheumatology 1995;22:2062-2064
Esdaile JM, Joseph L, Mackenzie T, Kashgarian M, Hayslett JP.
The benefit of early treatment with immunosuppressive agents in lupus nephritis
The Journal of Rheumatology 1994;21:2046-51
Fraenkel L, Mackenzie T, Joseph L, Kashgarian M, Hayslett JP, Esdaile JM.
Response to treatment as a predictor of longterm outcome in patients with lupus nephritis
Journal of Rheumatology 1994;21(11):2052-2057
Esdaile JM, Joseph L, MacKenzie T, Kashgarian M, Hayslett JP.
The pathenogenesis and prognosis of lupus nephritis: Information from repeat renal biopsy
Seminars in Arthritis and Rheumatism 1993;23(2):135-148
Mata S, Hill R, Joseph L, Kaplan P, Dussault R, Watts C, Fitzcharles M, Shiroky J, Fortin PR, Esdaile JM.
Chest radiographs as a screening test for diffuse idiopathic skeletal hyperostosis
The Journal of Rheumatology 1993;20:1905-10