Selected publications

Benlimame N, He Q, Jie S, Xiao D, Xu YJ, Loignon M, Schlaepfer DD, and Alaoui-Jamali MA. FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion. Journal of Cell Biology, in press.

Balys R, Alaoui-Jamali MA, Black M, and Hier M. A clinically relevant oral cancer model for serum proteomics eavesdropping on the tumor microenvironment. Journal of Otolaryngology, in press.

Brahimi F, Rachid Z, McNamee JP, Alaoui-Jamali MA, Tari AM, Jean-Claude BJ. Mechanism of action of a novel "combi-triazene" engineered to possess a polar functional group on the alkylating moiety: evidence for enhancement of potency. Biochem Pharmacol. 2005 Aug 15;70(4):511-9. {PDF}

Mamane Y, Loignon M, Palmer J, Hernandez E, Cesaire R, Alaoui-Jamali M, Hiscott J. Repression of DNA repair mechanisms in IRF-4-expressing and HTLV-I-infected T lymphocytes. J Interferon Cytokine Res. 2005 Jan;25(1):43-51. {PDF}

Mathonnet G, Lachance S, Alaoui-Jamali M, Drobetsky EA. Expression of hepatitis B virus X oncoprotein inhibits transcription-coupled nucleotide excision repair in human cells. Mutat Res. 2004 Oct 4;554(1-2):305-18. {PDF}

Matheson SL, McNamee JP, Wang T, Alaoui-Jamali MA, Tari AM, Jean-Claude B. The combi-targeting concept : dissection of the binary mechanism of action of the combi-triazene SMA41 in vitro and antitumor. J Pharmacol Exp Ther. 2004 Sep 9; 311(3):1163-70.  {PDF}

Chow TY, Alaoui-Jamali MA, Yeh C, Yuen L, Griller D. The DNA double-stranded break repair protein endo-exonuclease as a therapeutic target for cancer. Mol Cancer Ther. 2004 Aug;3(8):911-9. {PDF}

Al Moustafa AE, Foulkes WD, Wong A, Jallal H, Batist G, Yu Q, Herlyn M, Sicinski P, Alaoui-Jamali MA. Cyclin D1 is essential for neoplastic transformation induced by both E6/E7 and E6/E7/ErbB-2 cooperation in normal cells. Oncogene. 2004 Jul 1;23(30):5252-6. {PDF}

Kandouz M, Bier A, Carystinos GD, Alaoui-Jamali MA, Batist G. Connexin43 pseudogene is expressed in tumor cells and inhibits growth. Oncogene. 2004 Jun 10;23(27):4763-70. {PDF}

Al Moustafa AE, Foulkes WD, Benlimame N, Wong A, Yen L, Bergeron J, Batist G, Alpert L, Alaoui-Jamali MA.
E6/E7 proteins of HPV type 16 and ErbB-2 cooperate to induce neoplastic transformation of primary normal oral epithelial cells. Oncogene. 2004 Jan 15;23(2):350-8.  {PDF}

Aloyz R, Grzywacz K, Xu ZY, Loignon M, Alaoui-Jamali MA, Panasci L.
Imatinib sensitizes CLL lymphocytes to chlorambucil. Leukemia. 2004 Mar;18(3):409-14.  {PDF}

Qin H, Shao Q, Thomas T, Kalra J, Alaoui-Jamali MA, Laird DW.
Connexin26 regulates the expression of angiogenesis-related genes in human breast tumor cells by both GJIC-dependent and -independent mechanisms. Cell Commun Adhes. 2003 Jul-Dec;10(4-6):387-93. {PDF}

Scrivens PJ, Alaoui-Jamali MA, Giannini G, Wang T, Loignon M, Batist G, Sandor VA.
Cdc25A-inhibitory properties and antineoplastic activity of bisperoxovanadium analogues.
Mol Cancer Ther. 2003 Oct;2(10):1053-9.{PDF}

Alaoui-Jamali MA, Song DJ, Benlimame N, Yen L, Deng X, Hernandez-Perez M, Wang T.
Regulation of multiple tumor microenvironment markers by overexpression of single or paired combinations of ErbB receptors. Cancer Res. 2003 Jul 1;63(13):3764-74. {PDF}

Qin H, Shao Q, Igdoura SA, Alaoui-Jamali MA, Laird DW.
Lysosomal and proteasomal degradation play distinct roles in the life cycle of Cx43 in gap junctional intercellular communication-deficient and -competent breast tumor cells.
J Biol Chem. 2003 Aug 8;278(32):30005-14. Epub 2003 May 26. {PDF}

Hamilton D, Wu JH, Alaoui-Jamali M, Batist G.
A novel missense mutation in the gamma-glutamylcysteine synthetase catalytic subunit gene causes both decreased enzymatic activity and glutathione production.
Blood. 2003 Jul 15;102(2):725-30. Epub 2003 Mar 27.{PDF}

Carystinos GD, Kandouz M, Alaoui-Jamali MA, Batist G.
Unexpected induction of the human connexin 43 promoter by the ras signaling pathway is mediated by a novel putative promoter sequence.
Mol Pharmacol. 2003 Apr;63(4):821-31. {PDF}

Panasci L, Stinson S, Melnychuk D, Sandor V, Miller W, Batist G, Patenaude
F, Bangash N, Panarello L, Alaoui-Jamali MA
and Sausville E, SarCNU, a
nitrosourea analogue on a day 1, 5 and 9 oral schedule: A phase I and
pharmacokinetic study in patients with advanced solid tumors, Journal
Clinical Oncology, 21: 232-240, 2003. {PDF}

Yen L, Benlimame N, Nie ZR, Xiao D, Wang T, Moustafa AE, Esumi H, Milanini J, Hynes NE, Pages G, Alaoui-Jamali MA. Differential Regulation of Tumor Angiogenesis by Distinct ErbB Homo- and Heterodimers. Molecular Bioliology of the Cell. 2002 Nov;13(11):4029-4044. {PDF}

Aloyz R, Xu Z-Y, Bello V, Bergeron J, Han F-Y, Yan Y, Malapetsa A,
Alaoui-Jamali MA,
Duncan AMV, and Panasci L. Regulation of cisplatin
resistance and homologous recombinational repair by the TFIIH subunit XPD.
Cancer Res. , 62: 5457-5462, 2002 {PDF}

Al Moustafa AE, Yen L, Benlimame N, Alaoui-Jamali MA. Regulation of
E-cadherin/catenin complex patterns by epidermal growth factor receptor
modulation in human lung cancer cells.
Lung Cancer. 2002 Jul;37(1):49-56 {PDF}

Xu Z, Chen ZP, Malapetsa A, Alaoui-Jamali MA, Bergeron J, Monks A, Myers TG, Mohr G, Sausville EA, Scudiero DA, Aloyz R, Panasci LC. DNA repair protein levels vis-a-vis anticancer drug resistance in the human tumor cell lines of the National Cancer Institute drug screening program. Anticancer Drugs. 2002 Jun;13(5):511-9. {PDF}

Qin H, Shao Q, Curtis H, Galipeau J, Belliveau DJ, Wang T, Alaoui-Jamali MA, Laird DW. Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication. Journal Biological Chemistry. 2002 May 31 {PDF}

Al Moustafa AE, Alaoui-Jamali MA, Batist G, Hernandez-Perez M, Serruya C, Alpert L, Black MJ, Sladek R, Foulkes WD. Identification of genes associated with head and neck carcinogenesis by cDNA microarray comparison between matched primary normal epithelial and squamous carcinoma cells. Oncogene. 2002 Apr 18;21(17):2634-40. {PDF}

Dupont E, Falardeau P, Mousa SA, Dimitriadou V, Pepin MC, Wang T, Alaoui-Jamali MA. Antiangiogenic and antimetastatic properties of Neovastat (AE-941), an orally active extract derived from cartilage tissue. Clinical Experimental Metastasis. 2002;19(2):145-53.

Barsalou A, Dayan G, Anghel SI, Alaoui-Jamali MA, Van de Velde P, Mader S. Growth-stimulatory and transcriptional activation properties of raloxifene in human endometrial Ishikawa cells. Mol Cell Endocrinol. 2002 Apr 25;190 (1-2):65-73 .{PDF}

Jaitovich-Groisman I, Benlimame N, Slagle BL, Perez MH, Alpert L, Song DJ, Fotouhi-Ardakani N, Galipeau J, Alaoui-Jamali MA. Transcriptional regulation of the TFIIH transcription repair components XPB and XPD by the hepatitis B virus x protein in liver cells and transgenic liver tissue. Journal Biological Chemistry. 276 (17):14124-32, 2001 {PDF}

Prudencio J, Akutsu N, Benlimame N, Wang T, Bastien Y, Lin R, Black MJ, Alaoui-Jamali MA, White JH. Action of low calcemic 1alpha,25-dihydroxyvitamin d(3) analogue eb1089 in head and neck squamous cell carcinoma. Journal of the National Cancer Institute. 93(10):745-53, 2001. {PDF}

Marcantonio D, Chalifour LE, Alaoui-Jamali MA, Alpert L, Huynh HT. Cloning and Characterization of a Novel Gene That Is Regulated by Estrogen and Is Associated with Mammary Gland Carcinogenesis. Endocrinology. 142(6):2409-2418, 2001. {PDF}

Huynh H, Alpert L, Alaoui-Jamali MA, Ng CY, Chan TW. Co-administration of finasteride and the pure anti-oestrogen ICI 182,780 act synergistically in modulating the IGF system in rat prostate. J Endocrinol. 2001 Oct;171(1):109-18. {PDF}

Huynh HT, Alpert L, Laird DW, Batist G, Chalifour L, Alaoui-Jamali MA. Regulation of the gap junction connexin 43 gene by androgens in the prostate. Journal Molecular Endocrinology 26(1):1-10, 2001. {PDF}

Jaitovitch-Groisman I, Fotouhi-Ardakani N, Schecter RL, Woo A, Alaoui-Jamali
MA, and Batist G.
Modulation of Glutathione S-Transferase Alpha by Hepatitis B Virus
and the Chemopreventive Drug Oltipraz. Journal Biological Chemistry, 275:
33395-33403, 2000 {PDF}

Cho JM, Song DJ, Bergeron JM, Benlimame N, Benlimame N, Wold MS, and Alaoui-Jamali MA. RBT1, a novel transcriptional coactivator, binds the second subunit of replication protein A. Nucleic Acids Research, 28 (18): 3478-3485, 2000.

Bergeron J, Benlimame N, Xeng-Rong N, Scrivens J, Koromilas A, and Alaoui-Jamali MA. Identification of the interferon-inducible double-stranded RNA-dependent protein kinase as a regulator of cellular response to bulky adducts. Cancer Research, 60: 6800-6804, 2000. {PDF}

Yen L, You XL, Al Moustafa A-E, Batist G, Hynes N, Mader S, Meloche S, and Alaoui-Jamali MA. Heregulin selectively upregulates vascular endothelial growth factor in cancer cells and stimulates angiogenesis. Oncogene, 19: 3460-3469, 2000 {PDF}

Sohn S, Benlimame N, Jaitovitch-Groisman I, Galipeau J, Batist G, and Alaoui-Jamali MA. Retroviral expression of the hepatitis B virus x gene promotes liver cell susceptibility to carcinogen-induced site specific mutagenesis. Mutation Research (DNA Repair), 460: 17-28, 2000 {PDF}

Groisman IJ. Koshy R. Henkler F. Groopman JD. Alaoui-Jamali MA.
Downregulation of DNA excision repair by the hepatitis B virus-x protein
occurs in p53-proficient and p53-deficient cells. Carcinogenesis, 20:
479-483, 1999. {PDF}

Laird D, Fistouris P, Batist G, Alpert L, Huynh HT, Carystinos GD, and Alaoui-Jamali MA. Deficiency of connexin 43 gap junctions is an independent marker for early breast tumors. Cancer Research, 59: 4104-4110, 1999 {PDF}

Selected books and invited reviews

Alaoui-Jamali MA, Scrivens PJ, and Loignon M. Stress-activated signal transduction pathways in DNA damage response: implications for repair, arrest, and therapeutic interventions. In “DNA Repair in Cancer Therapy”, Editors: L Panasci and MA Alaoui-Jamali, Humana Press Inc., NJ; 2004.

Luh S-P and Alaoui-Jamali MA. New targets, new agents, and the evolving phenomena of drug resistance. Current Cancer Therapy Reviews, in press.

Alaoui-Jamali MA, Dupre I, Qiang H. Prediction of drug sensitivity and drug resistance in cancer by transcriptional and proteomic profiling. Drug Resistance Updates;7(4-5):245-255, 2004. {PDF}

Alaoui-Jamali MA and Qiang H. The interface between ErbB and non-ErbB receptors in tumor invasion: clinical implications and opportunities for target discovery. Drug Resistance Updates, Apr;6(2):95-107, 2003. {PDF}

Batist G, Schecter RL, and Alaoui Jamali MA. The glutathione system and drug resistance. In: Principles of Cancer Drug Pharmacology, Edited by Schilsky LR, Milano GA, and Ratain JM, Marcel Dekker Publications, Chapter 23, pp 503-521, 1996.