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| Research interests: Regulation of picornavirus and hepatitis C virus (HCV) protein synthesis. Recent publications: Costa-Mattioli M, Svitkin Y and Sonenberg N (2004) La autoantigen is necessary for optimal function of the poliovirus and hepatitis C virus internal ribosome entry site in vivo and in vitro. Mol Cell Biol 24: 6861-6870 Kahvejian A, Svitkin YV, Sukarieh R, M.-N. MB and Sonenberg N (2005) Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms. Genes Dev 19: 104-113 Svitkin YV, Gradi A, Imataka H, Morino S and Sonenberg N (1999) Eukaryotic initiation factor 4GII (eIF4GII), but not eIF4GI, cleavage correlates with inhibition of host cell protein synthesis after human rhinovirus infection. J Virol 73: 3467-3472 Svitkin YV, Hahn H, Gingras AC, Palmenberg AC and Sonenberg N (1998) Rapamycin and wortmannin enhance replication of a defective encephalomyocarditis virus. J Virol 72: 5811-5819 Svitkin YV, Imataka H, Khaleghpour K, Kahvejian A, Liebig HD and Sonenberg N (2001) Poly(A)-binding protein interaction with eIF4G stimulates picornavirus IRES-dependent translation. RNA 7: 1743-1752 Svitkin YV, Ovchinnikov LP, Dreyfuss G and Sonenberg N (1996) General RNA binding proteins render translation cap dependent. EMBO J 15: 7147-7155 Svitkin YV, Pause A, Haghighat A, Pyronnet S, Witherell G, Belsham GJ and Sonenberg N (2001) The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure. RNA 7: 382-394 Svitkin YV and Sonenberg N (2003) Cell-free synthesis of encephalomyocarditis virus. J Virol 77: 6551-6555 Svitkin YV and Sonenberg N (2004) An efficient system for cap- and poly(A)-dependent translation in vitro. Methods Mol Biol 257: 155-170
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