Publications

Link to Top 20 Publications

2017

1. Wu E, Vashisht AA, Chapat C, Flamand MN, Cohen E, Sarov M, Tabach Y, Sonenberg N, Wohlschlegel J, Duchaine TF. A continuum of mRNP complexes in embryonic microRNA-mediated silencing. Nucleic Acids Res. 2017 Feb 28;45(4):2081-2098.


2016

1. Skałecka A, Liszewska E, Bilinski R, Gkogkas C, Khoutorsky A, Malik AR, Sonenberg N, Jaworski J. mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons. Dev Neurobiol. 2016 Mar 23. doi: 10.1002/dneu.22392. [Epub ahead of print]

2. Wang F, Alain T, Szretter KJ, Stephenson K, Pol JG, Atherton MJ, Hoang HD, Fonseca BD, Zakaria C, Chen L, Rangwala Z, Hesch A, Chan ES, Tuinman C, Suthar MS, Jiang Z, Ashkar AA, Thomas G, Kozma SC, Gale M Jr, Fitzgerald KA, Diamond MS, Mossman K, Sonenberg N, Wan Y, Lichty BD. S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3. Nat Immunol. 2016 May;17(5):514-22.

3. Blandino-Rosano M, Scheys JO, Jimenez-Palomares M, Barbaresso R, Bender AS, Yanagiya A, Liu M, Rui L, Sonenberg N, Bernal-Mizrachi E. 4E-BP2/SH2B1//IRS2 are part of a novel feedback loop that controls β-cell mass. Diabetes. 2016 May 23. pii: db151443. [Epub ahead of print]

4. So L, Lee J, Palafox M, Mallya S, Woxland CG, Arguello M, Truitt ML, Sonenberg N, Ruggero D, Fruman DA. The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes. Sci Signal. 2016 May 31;9(430):ra57. doi: 10.1126/scisignal.aad8463.

5. Tsukumo Y, Alain T, Fonseca BD, Nadon R, Sonenberg N. Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3. Nat Commun. 2016 Jun 20;7:11776.

6. Zuberek J, Kuchta K, Hernández G, Sonenberg N, Ginalski K. Diverse cap-binding properties of Drosophila eIF4E isoforms. Biochim Biophys Acta. 2016 Oct;1864(10):1292-303.

7. Penney J, Tsurudome K, Liao EH, Kauwe G, Gray L, Yanagiya A, R Calderon M, Sonenberg N, Haghighi AP. LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction. Nat Commun. 2016 Jul 19;7:12188.

8. Bhat M, Yanagiya A, Graber T, Razumilava N, Bronk S, Zammit D, Zhao Y, Zakaria C, Metrakos P, Pollak M, Sonenberg N, Gores G, Jaramillo M, Morita M, Alain T. Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells. Oncotarget. 2016 Jul 18. doi: 10.18632/oncotarget.10671. [Epub ahead of print]

9. Chio II, Jafarnejad SM, Ponz-Sarvise M, Park Y, Rivera K, Palm W, Wilson J, Sangar V, Hao Y, Öhlund D, Wright K, Filippini D, Lee EJ, Da Silva B, Schoepfer C, Wilkinson JE, Buscaglia JM, DeNicola GM, Tiriac H, Hammell M, Crawford HC, Schmidt EE, Thompson CB, Pappin DJ, Sonenberg N, Tuveson DA. NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer. Cell. 2016 Aug 11;166(4):963-76.

10. Signer RA, Qi L, Zhao Z, Thompson D, Sigova AA, Fan ZP, DeMartino GN, Young RA, Sonenberg N, Morrison SJ. The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs. Genes Dev. 2016 Aug 1;30(15):1698-703.

11. Tsukumo Y, Sonenberg N, Alain T. Transcriptional induction of 4E-BP3 prolongs translation repression. Cell Cycle. 2016 Aug 26:0. [Epub ahead of print]


2015

1. Faller WJ, Jackson TJ, Knight JR, Ridgway RA, Jamieson T, Karim SA, Jones C, Radulescu S, Huels DJ, Myant KB, Dudek KM, Casey HA, Scopelliti A, Cordero JB, Vidal M, Pende M, Ryazanov AG, Sonenberg N, Meyuhas O, Hall MN, Bushell M, Willis, AE, Sansom OJ. mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature. 2015 Jan 22; 517(7535):497-500.

2. Pelletier J, Graff J, Ruggero D, Sonenberg N. Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development. (Review) Cancer Res. 2015 Jan 15;75(2):250-63.

3. Bah A, Vernon RM, Siddiqui Z, Krzeminski M, Muhandiram R, Zhao C, Sonenberg N, Kay LE, Forman-Kay JD. Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch. Nature. 2015 Mar 5;519(7541):106-9.

4. Sinvani H, Haimov O, Svitkin Y, Sonenberg N, Tamarkin-Ben-Harush A, Viollet B, Dikstein R. Translational tolerance of mitochondrial genes to metabolic energy stress involves TISU and eIF1-eIF4GI cooperation in start codon selection. Cell Metabolism. 2015 Mar 3; 21(3):479-92.

5. Im YK, La Selva R, Gandin V, Ha JR, Sabourin V, Sonenberg N, Pawson T, Topisirovic I, Ursini-Siegel J. The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner. Oncogene. 2015 Mar 26; 34(13):1729-35.

6. Arulanandam R, Batenchuk C, Varette O, Zakaria C, Garcia V, Forbes NE, Davis C, Krishnan R, Karmacharya R, Cox J, Sinha A, Babawy A, Waite K, Weinstein E, Falls T, Chen A, Hamill J, De Silva N, Conrad DP, Atkins H, Garson K, Ilkow C, Kærn M, Vanderhyden B, Sonenberg N, Alain T, Le Boeuf F, Bell JC, Diallo JS. Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing. Nature Communications. 2015 Mar 30; 6:6410.

7. Liberman N, Gandin V, Svitkin YV, David M, Virgili G, Jaramillo M, Holcik M, Nagar B, Kimchi A, Sonenberg N. DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation. Nucleic Acids Research. 2015 Apr 20; 43(7):3764-75.

8. Bhat M, Robichaud N, Hulea L, Sonenberg N, Pelletier J, Topisirovic I. Targeting the translation machinery in cancer. (Review) Nature Reviews: Drug Discovery. 2015 Apr; 14(4):261-78.

9. Filipowicz W, Sonenberg N. The long unfinished march towards understanding microRNA-mediated repression. RNA. 2015 Apr; 21(4):519-24.

10. Robichaud N, Del Rincon SV, Huor B, Alain T, Petruccelli LA, Hearnden J, Goncalves C, Grotegut S, Spruck CH, Furic L, Larsson O, Muller WJ, Miller WH, Sonenberg N. Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3. Oncogene. 2015 Apr 16; 34(16):2032-42.

11. Aulas A, Caron G, Gkogkas CG, Mohamed NV, Destroismaisons L, Sonenberg N, Leclerc N, Parker JA, Vande Velde C. G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA. Journal of Cell Biology. 2015 Apr 13; 209(1):73-84.

12. Martinez A, Sese M, Losa JH, Robichaud N, Sonenberg N, Aasen T, Ramón Y Cajal S. Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches. PLoS One. 2015 Apr 29; 10(4):e0123352.

13. Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N. Light-regulated translational control of circadian behavior by eIF4E phosphorylation. Nature Neuroscience. 2015 Jun; 18(6):855-62.

14. Topisirovic I, Sonenberg N. Translation and cancer. Biochimica Biophys Acta. 2015 Jul;1849(7):751-2.

15. Zidek LM, Ackermann T, Hartleben G, Eichwald S, Kortman G, Kiehntopf M, Leutz A, Sonenberg N, Wang ZQ, von Maltzahn J, Müller C, Calkhoven CF. Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice. EMBO Rep. 2015 Aug;16(8):1022-36.

16. Aguilar-Valles A, Matta-Camacho E, Khoutorsky A, Gkogkas C, Nader K, Lacaille JC, Sonenberg N. Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2. J Neurosci. 2015 Aug 5;35(31):11125-32.

17. Maity S, Rah S, Sonenberg N, Gkogkas CG, Nguyen PV. Norepinephrine triggers metaplasticity of LTP by increasing translation of specific mRNAs. Learn Mem. 2015 Sep 15;22(10):499-508.

18. Siddiqui N, Sonenberg N. Signalling to eIF4E in cancer. (Review) Biochem Soc Trans. 2015 Oct 1;43(5):763-72.

19. Khoutorsky A, Bonin RP, Sorge RE, Gkogkas CG, Pawlowski SA, Jafarnejad SM, Pitcher MH, Alain T, Perez-Sanchez J, Salter EW, Martin L, Ribeiro-da-Silva A, De Koninck Y, Cervero F, Mogil JS, Sonenberg N. Translational control of nociception via 4E-binding protein 1. Elife. 2015 Dec 18;4. pii: e12002.


2014

1. Gkogkas CG, Khoutorsky A, Cao R, Jafarnejad SM, Prager-Khoutorsky M, Giannakas N, Kaminari A, Fragkouli A, Nader K, Price TJ, Konicek BW, Graff JR, Tzinia AK, Lacaille JC, Sonenberg N. Pharmacogenetic Inhibition of eIF4E-Dependent Mmp9 mRNA Translation Reverses Fragile X Syndrome-like Phenotypes. Cell Rep. 2014 Dec 11;9(5):1742-55.

2. Faller WJ, Jackson TJ, Knight JR, Ridgway RA, Jamieson T, Karim SA, Jones C, Radulescu S, Huels DJ, Myant KB, Dudek KM, Casey HA, Scopelliti A, Cordero JB, Vidal M, Pende M, Ryazanov AG, Sonenberg N, Meyuhas O, Hall MN, Bushell M, Willis AE, Sansom OJ. mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature. 2014 Nov 5.

3. Fukao A, Mishima Y, Takizawa N, Oka S, Imataka H, Pelletier J, Sonenberg N, Thoma C, Fujiwara T. MicroRNAs trigger dissociation of eIF4AI and eIF4AII from target mRNAs in humans. Mol Cell. 2014 Oct 2;56(1):79-89.

4. Topisirovic I, Sonenberg N. Distinctive tRNA repertoires in proliferating versus differentiating cells. Cell. 2014 Sep 11;158(6):1238-9.

5. Ramon Y Cajal S, De Mattos-Arruda L, Sonenberg N, Cortes J, Peg V. The intra-tumor heterogeneity of cell signaling factors in breast cancer: p4E-BP1 and peIF4E are diffusely expressed and are real potential targets. Clin Transl Oncol. 2014 Nov;16(11):937-41.

6. Rouya C, Siddiqui N, Morita M, Duchaine TF, Fabian MR, Sonenberg N. Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1. RNA. 2014 Sep;20(9):1398-409.

7. Sun Y, Atas E, Lindqvist LM, Sonenberg N, Pelletier J, Meller A. Single-molecule kinetics of the eukaryotic initiation factor 4AI upon RNA unwinding. Structure. 2014 Jul 8;22(7):941-8.

8. Robichaud N, Del Rincon SV, Huor B, Alain T, Petruccelli LA, Hearnden J, Goncalves C, Grotegut S, Spruck CH, Furic L, Larsson O, Muller WJ, Miller WH, Sonenberg N. Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3. Oncogene. 2014 Jun 9.

9. Liew CW, Assmann A, Templin AT, Raum JC, Lipson KL, Rajan S, Qiang G, Hu J, Kawamori D, Lindberg I, Philipson LH, Sonenberg N, Goldfine AB, Stoffers DA, Mirmira RG, Urano F, Kulkarni RN. Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):E2319-28.

10. Piccirillo CA, Bjur E, Topisirovic I, Sonenberg N, Larsson O. Translational control of immune responses: from transcripts to translatomes. Nat Immunol. 2014 Jun;15(6):503-11.

11. Im YK, La Selva R, Gandin V, Ha JR, Sabourin V, Sonenberg N, Pawson T, Topisirovic I, Ursini-Siegel J. The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner. Oncogene. 2014 May 19.

12. Jung H, Gkogkas CG, Sonenberg N, Holt CE. Remote control of gene function by local translation. Cell. 2014 Mar 27;157(1):26-40.

13. Yamamoto K, Gandin V, Sasaki M, McCracken S, Li W, Silvester JL, Elia AJ, Wang F, Wakutani Y, Alexandrova R, Oo YD, Mullen PJ, Inoue S, Itsumi M, Lapin V, Haight J, Wakeham A, Shahinian A, Ikura M, Topisirovic I, Sonenberg N, Mak TW. Largen: a molecular regulator of mammalian cell size control. Mol Cell. 2014 Mar 20;53(6):904-15.

14. Tahmasebi S, Alain T, Rajasekhar VK, Zhang JP, Prager-Khoutorsky M, Khoutorsky A, Dogan Y, Gkogkas CG, Petroulakis E, Sylvestre A, Ghorbani M, Assadian S, Yamanaka Y, Vinagolu-Baur JR, Teodoro JG, Kim K, Yang XJ, Sonenberg N. Multifaceted regulation of somatic cell reprogramming by mRNA translational control. Cell Stem Cell. 2014 May 1;14(5):606-16.

15. Gigoux M, Lovato A, Leconte J, Leung J, Sonenberg N, Suh WK. Inducible costimulator facilitates T-dependent B cell activation by augmenting IL-4 translation. Mol Immunol. 2014 May;59(1):46-54.

16. Martineau Y, Wang X, Alain T, Petroulakis E, Shahbazian D, Fabre B, Bousquet-Dubouch MP, Monsarrat B, Pyronnet S, Sonenberg N. Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase. Mol Cell Biol. 2014 Mar;34(6):1046-53.

17. Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T. Parallel measurement of dynamic changes in translation rates in single cells. Nat Methods. 2014 Jan;11(1):86-93.



2013

1. Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T. Parallel measurement of dynamic changes in translation rates in single cells. Nat Methods. 2013 Nov 10. [Epub ahead of print]

2. Lukhele S, Bah A, Lin H, Sonenberg N, Forman-Kay JD. Interaction of the Eukaryotic Initiation Factor 4E with 4E-BP2 at a Dynamic Bipartite Interface. Structure. 2013 Oct 23. [Epub ahead of print]

3. Morita M, Gravel SP, Chénard V, Sikström K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, Larsson O, St-Pierre J, Topisirovic I, Sonenberg N. mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation. Cell Metab. 2013 Nov 5;18(5):698-711.

4. Cao R, Robinson B, Xu H, Gkogkas C, Khoutorsky A, Alain T, Yanagiya A, Nevarko T, Liu AC, Amir S, Sonenberg N. Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling. Neuron. 2013 Aug 21;79(4):712-24.

5. Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, Renslo AR, Sonenberg N, Walter P. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2013 May 28;2:e00498.

6. Hernández G, Miron M, Han H, Liu N, Magescas J, Tettweiler G, Frank F, Siddiqui N, Sonenberg N, Lasko P. Mextli is a Novel eIF4E-Binding Protein that Promotes Translation in Drosophila. Mol Cell Biol. 2013 May 28. [Epub ahead of print]

7. Svitkin YV, Yanagiya A, Karetnikov AE, Alain T, Fabian MR, Khoutorsky A, Perreault S, Topisirovic I, Sonenberg N. Control of Translation and miRNA-Dependent Repression by a Novel Poly(A) Binding Protein, hnRNP-Q. PLoS Biol. 2013 May 21;11(5):e1001564. Epub

8. Bjur E, Larsson O, Yurchenko E, Zheng L, Gandin V, Topisirovic I, Li S, Wagner CR,
Sonenberg N, Piccirillo CA. Distinct Translational Control in CD4(+) T Cell Subsets. PLoS Genet. 2013 May 9(5):e1003494. Epub

9. Fabian MR, Frank F, Rouya C, Siddiqui N, Lai WS, Karetnikov A, Blackshear PJ,
Nagar B, Sonenberg N. Structural basis for the recruitment of the human CCR4-NOT
deadenylase complex by tristetraprolin. Nat Struct Mol Biol. 2013 May 5. [Epub ahead of print]

10. Khoutorsky A, Yanagiya A, Gkogkas CG, Fabian MR, Prager-Khoutorsky M, Cao R,
Gamache K, Bouthiette F, Parsyan A, Sorge RE, Mogil JS, Nader K, Lacaille JC, Sonenberg N. Control of Synaptic Plasticity and Memory via Suppression of Poly(A)-Binding Protein. Neuron. 2013 Apr 24;78(2):298-311.

11. Gandin V, Gutierrez GJ, Brill LM, Varsano T, Feng Y, Aza-Blanc P, Au Q,McLaughlan
S, Ferreira TA, Alain T, Sonenberg N, Topisirovic I, Ronai ZA. Degradation of newly synthesized polypeptides by ribosome-associatedRACK1/JNK/eEF1A2 complex. Mol Cell Biol. 2013 Apr 22. [Epub ahead of print]

12. Melemedjian OK, Khoutorsky A, Sorge RE, Yan J, Asiedu MN, Valdez A, GhoshS,Dussor G, Mogil JS, Sonenberg N, Price TJ. mTORC1 inhibition induces pain viaIRS-1-dependent feedback activation of ERK. Pain. 2013 Mar 15. [Epub ahead of print]

13. Chaveroux C, Eichner LJ, Dufour CR, Shatnawi A, Khoutorsky A, Bourque G, Sonenberg N, Giguère V. Molecular and Genetic Crosstalks between mTOR and ERRα Are Key Determinants of Rapamycin-Induced Nonalcoholic Fatty Liver. CellMetab.2013 Apr 2;17(4):586-98.

14. Fournier MJ, Coudert L, Mellaoui S, Adjibade P, Gareau C, Côté MF, Sonenberg N, Gaudreault RC, Mazroui R. Inactivation of the mTORC1-eIF4E Pathway alters Stress Granules Formation. Mol Cell Biol. 2013 Apr 1. [Epub ahead of print]

15. Virgili G, Frank F, Feoktistova K, Sawicki M, Sonenberg N, Fraser CS, Nagar B. Structural Analysis of the DAP5 MIF4G Domain and Its Interaction with eIF4A. Structure. 2013 Mar 5. [Epub ahead of print]

16. Tamai T, Yamaguchi O, Hikoso S, Takeda T, Taneike M, Oka T, Oyabu J, Murakawa
T, Nakayama H, Uno Y, Horie K, Nishida K, Sonenberg N, Shah AM, Takeda J, Komuro
I, Otsu K. Ras Homologue Enriched in Brain (Rheb)-dependent mTORC1 Activation Becomes Indispensable for Cardiac Hypertrophic Growth after Early Postnatal Period. J Biol Chem. 2013 Feb 20. [Epub ahead of print]

17. Bhat M, Sonenberg N, Gores G. The mTOR pathway in hepatic malignancies. Hepatology. 2013 Feb 13. [Epub ahead of print]

18. Stern E, Chinnakkaruppan A, David O, Sonenberg N, Rosenblum K. Blocking the eIF2α kinase (PKR) enhances positive and negative forms of cortex-dependent taste memory. J Neurosci. 2013 Feb 6;33(6):2517-25.

19. Ran I, Gkogkas CG, Vasuta C, Tartas M, Khoutorsky A, Laplante I, Parsyan A, Nevarko T, Sonenberg N, Lacaille JC. Selective regulation of GluA subunit synthesis and AMPA receptor-mediated synaptic function and plasticity by the translation repressor 4E-BP2 in hippocampal pyramidal cells. J Neurosci. 2013 Jan 30;33(5):1872-86.

20. Hershey JW, Sonenberg N, Mathews MB. Principles of translational control: an overview. Cold Spring Harb Perspect Biol. 2012 Dec 1:4(12).

21. Larsson O, Tian B, Sonenberg N. Toward a genome-wide landscape of translational control. Cold Spring Harb Perspect Biol. 2013 Jan 1;5(1):a012302.

22. Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N. Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature. 2013 Jan 17;493(7432):371-7.



2012


1. Alain T, Morita M, Fonseca BD, Yanagiya A, Siddiqui N, Bhat M, Zammit D, Marcus V, Metrakos P, Voyer LA, Gandin V, Liu Y, Topisirovic I, Sonenberg N: eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies. Cancer Res. 2012 Oct 24. [Epub ahead of print]

2. Mohr I, Sonenberg N: Host translation at the nexus of infection and immunity.Cell Host Microbe. 2012 Oct 18;12(4):470-83.

3. Hernández G, Han H, Gandin V, Fabian L, Ferreira T, Zuberek J, Sonenberg N, Brill JA, Lasko P: Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila. Development. 2012 Sep;139(17):3211-20.

4. Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, Alain T, Fonseca BD, Karashchuk G, Bennett CF, Kabuta T, Higashi S, Larsson O, Topisirovic I, Smith RJ, Gingras AC, Sonenberg N: A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Mol Cell Biol. 2012 Sep;32(17):3585-93.

5. Frank F, Hauver J, Sonenberg N, Nagar B: Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs. The EMBO journal 2012, 31(17):3588-3595.

6. Hernandez G, Han H, Gandin V, Fabian L, Ferreira T, Zuberek J, Sonenberg N, Brill JA, Lasko P: Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila. Development 2012, 139(17):3211-3220.

7. Sonenberg N, Filipowicz W: Retrospective. Aaron Shatkin (1934-2012). Science 2012, 337(6092):309.

8. Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, Alain T, Fonseca BD, Karashchuk G, Bennett CF et al: A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development. Molecular and cellular biology 2012, 32(17):3585-3593.

9. Tettweiler G, Kowanda M, Lasko P, Sonenberg N, Hernandez G: The Distribution of eIF4E-Family Members across Insecta. Comparative and functional genomics 2012, 2012:960420.

10. Fabian MR, Sonenberg N: The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC. Nature structural & molecular biology 2012, 19(6):586-593.

11. Larsson O, Morita M, Topisirovic I, Alain T, Blouin MJ, Pollak M, Sonenberg N: Distinct perturbation of the translatome by the antidiabetic drug metformin. Proceedings of the National Academy of Sciences of the United States of America 2012, 109(23):8977-8982.

12. Yanagiya A, Suyama E, Adachi H, Svitkin YV, Aza-Blanc P, Imataka H, Mikami S, Martineau Y, Ronai ZA, Sonenberg N: Translational homeostasis via the mRNA cap-binding protein, eIF4E. Molecular cell 2012, 46(6):847-858.

13. Herdy B, Jaramillo M, Svitkin YV, Rosenfeld AB, Kobayashi M, Walsh D, Alain T, Sean P, Robichaud N, Topisirovic I et al: Translational control of the activation of transcription factor NF-kappaB and production of type I interferon by phosphorylation of the translation factor eIF4E. Nature immunology 2012, 13(6):543-550.

14. Srivastava T, Fortin DA, Nygaard S, Kaech S, Sonenberg N, Edelman AM, Soderling TR: Regulation of neuronal mRNA translation by CaM-kinase I phosphorylation of eIF4GII. The Journal of neuroscience : the official journal of the Society for Neuroscience 2012, 32(16):5620-5630.

15. Penney J, Tsurudome K, Liao EH, Elazzouzi F, Livingstone M, Gonzalez M, Sonenberg N, Haghighi AP: TOR is required for the retrograde regulation of synaptic homeostasis at the Drosophila neuromuscular junction. Neuron 2012, 74(1):166-178.

16. Fonseca BD, Diering GH, Bidinosti MA, Dalal K, Alain T, Balgi AD, Forestieri R, Nodwell M, Rajadurai CV, Gunaratnam C et al: Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling. The Journal of biological chemistry 2012, 287(21):17530-17545.

17. Sun Y, Atas E, Lindqvist L, Sonenberg N, Pelletier J, Meller A: The eukaryotic initiation factor eIF4H facilitates loop-binding, repetitive RNA unwinding by the eIF4A DEAD-box helicase. Nucleic acids research 2012, 40(13):6199-6207.

18. Lin J, Fabian M, Sonenberg N, Meller A: Nanopore detachment kinetics of poly(A) binding proteins from RNA molecules reveals the critical role of C-terminus interactions. Biophysical journal 2012, 102(6):1427-1434.

19. Chenoweth MJ, Mian MF, Barra NG, Alain T, Sonenberg N, Bramson J, Lichty BD, Richards CD, Ma A, Ashkar AA: IL-15 can signal via IL-15Ralpha, JNK, and NF-kappaB to drive RANTES production by myeloid cells. J Immunol 2012, 188(9):4149-4157.

20. Li Z, Miard S, Laplante M, Sonenberg N, Picard F: Insulin stimulates IGFBP-2 expression in 3T3-L1 adipocytes through the PI3K/mTOR pathway. Molecular and cellular endocrinology 2012, 358(1):63-68.

21. Kundu P, Fabian MR, Sonenberg N, Bhattacharyya SN, Filipowicz W: HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA. Nucleic acids research 2012, 40(11):5088-5100.

22. Nogueira V, Sundararajan D, Kwan JM, Peng XD, Sarvepalli N, Sonenberg N, Hay N: Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis. The EMBO journal 2012, 31(5):1134-1146.

23. Delbes G, Yanagiya A, Sonenberg N, Robaire B: PABP interacting protein 2A (PAIP2A) regulates specific key proteins during spermiogenesis in the mouse. Biology of reproduction 2012, 86(3):95.

24. Fujiwara T, Fukao A, Sasano Y, Matsuzaki H, Kikkawa U, Imataka H, Inoue K, Endo S, Sonenberg N, Thoma C et al: Functional and direct interaction between the RNA binding protein HuD and active Akt1. Nucleic acids research 2012, 40(5):1944-1953.

25. Pons B, Armengol G, Livingstone M, Lopez L, Coch L, Sonenberg N, Ramon y Cajal S: Association between LRRK2 and 4E-BP1 protein levels in normal and malignant cells. Oncology reports 2012, 27(1):225-231.