The Schmeing Lab



Peer-reviewed articles and reviews

An up-to-date list is always available from Pubmed.

Alonzo DA*, Chiche-Lapierre C*, Tarry MJ, Wang J, Schmeing TM. Structural basis of keto acid utilization in nonribosomal depsipeptide synthesis. Published online Feb 17, 2020, Nature Chemical Biology

*Reimer JM, *Eivaskhani M, Harb I, Guarné A, Weigt M, Schmeing TM. Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility. Science. 2019 Nov 8; 366(6466). PMID: 31699907

Tarry MJ, Harmel C, Taylor J, Marczynski G, Schmeing TM. Structures of GapR reveal a central channel which could accommodate B-DNA. Sci Reports. 2019 Nov 13; 16679 PMID: 31723182

Layoun A, Goldberg AA, Baig A, Eng A, Attias O, Nelson K, Carella A, Amberber N, Fielhaber J, Joung KB, Schmeing TM, Han YS, Divangahi M, Downey J, Roux PP, Kristof AS. Regulation of PKC delta nuclear import and apoptosis by mechanistic target of rapamycin complex-1. Sci Reports. 2019 Nov 26; 9(1) 17620. PMID: 31772273

*Huguenin-Dezot N, *Alonzo DA, Heberlig GW, Mahesh M, Nguyen DP, Dornan MH, Boddy CN, **Schmeing TM, **Chin JW. Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid. Nature. 2019 Jan; 565(7737): 112-117. PMID: 30542153

Reimer JM, Harb I, Ovchinnikova OG, Jiang J, Whitfield C, Schmeing TM. Structural insight into a novel formyltransferase and evolution to a nonribosomal peptide synthetase tailoring domain. ACS Chem Bio. 2018 Nov 16;13(11):3161-3172. PMID: 30346688

Reimer JM, Haque AS, Tarry MJ, Schmeing TM. Piecing together nonribosomal peptide synthesis. Current Opinions in Structural Biology. 2018 Feb 11;49. PMID: 29444491

Langlais D, Cencic R, Moradin N, Kennedy JM, Ayi K, Tarry MJ, Schmeing M, Kain KC, Porco JA, Pelletier J, Gros P. Rocaglates as dual-targeting agents for severe malaria. Proc Nat Acad USA. 2018 Mar 6;115(10):E2366-E2375. PMID: 29463745

Bloudoff K, Schmeing TM. Structural and functional aspects of the nonribosomal peptide synthetase condensation domain superfamily: discovery, dissection and diversity. Biochim Biophys Acta. 2017 Nov;1865:1587-1604. PMID: 285256268

Tarry MJ, Haque AS, Bui KH, Schmeing TM. X-ray crystallography and electron microscopy of cross- and multi-module nonribosomal peptide synthetase proteins reveal a flexible architecture. Structure. 2017 May 2;25(5):783-793. PMID: 28434915

Bloudoff K, Fage CD, Marahiel MA, Schmeing TM. Structural and mutational analysis of the nonribosomal peptide synthetase heterocyclization domain provides insight into catalysis. Proc Natl Acad Sci USA. 2017 Jan 3;114(1):95-100. PMID: 27994138

Schmeing TM. Visualizing A Natural Antibiotic Nanofactory. Clin Invest Med. 2016 Dec 1;39(6):E220-E226. PMID: 27917781

Reimer JM, Aloise MN, Powell HR and Schmeing TM. Manipulation of an existing crystal form unexpectedly results in interwoven packing networks with pseudo-translational symmetry. Acta Crystallogr Sect D. 2016; 1;72 (Pt 10):1130-1136. PMID: 27710934

Bloudoff K, Alonzo DA, Schmeing TM. Chemical Probes Allow Structural Insight into the Condensation Reaction of Nonribosomal Peptide Synthetases. Cell Chem Biol. 2016 Mar 17;23(3). PMID: 26991102

Alonzo DA, Schmeing TM. Translation: Ribosomes make sweeping arrests. Nat Chem Biol. 2016 Feb 16;12(3). PMID: 26881763

Reimer JM, Aloise MN, Harrison PM, Schmeing TM. Synthetic cycle of the initiation module of a formylating nonribosomal peptide synthetase. Nature. 2016 Jan 14;529(7585). PMID: 26762462

Argyropoulos P, Bergeret F, Pardin C, Reimer JM, Pinto A, Boddy CN, Schmeing TM. Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis. Biochim Biophys Acta. 2016 Mar;1860(3). PMID: 26592346

Alonzo DA, Magarvey NA, Schmeing TM. Characterization of cereulide synthetase, a toxin-producing macromolecular machine. PLoS One. 2015 Jun 4;10(6). PMID: 26042597

Tarry MJ, Schmeing TM. Specific disulfide cross-linking to constrict the mobile carrier domain of nonribosomal peptide synthetases. Protein Eng Des Sel. 2015 Jun;28(6):163-70. PMID: 25713404

Cencic R, Miura H, Malina A, Robert F, Ethier S, Schmeing TM, Dostie J, Pelletier J. Protospacer Adjacent Motif (PAM)-Distal Sequences Engage CRISPR Cas9 DNA Target  Cleavage. PLoS One, 2014 Oct 2;9(10). PMID: 25275497

Bloudoff K, Rodionov D, Schmeing TM. Crystal Structures of the First Condensation Domain of CDA Synthetase Suggest Conformational Changes during the Synthetic Cycle of Nonribosomal Peptide Synthetases. J Mol Biol. 2013 Sep 9;425(17):3137-50. PMID: 23756159

Bloudoff K, Schmeing TM. Crystallization and preliminary crystallographic analysis of the first condensation domain of viomycin synthetase. Acta Crystallogr Sect F. 2013 Apr 1;69(Pt 4):412-5. PMID: 23545648

Schmeing TM*, Voorhees RM*, Kelley AC, Ramakrishnan V. How mutations in tRNA distant from the anticodon affect the fidelity of decoding. Nat Struct Mol Biol. 2011, Apr; 18(4):432-6. PMID: 21378964

Voorhees RM*, Schmeing TM*, Kelley AC, Ramakrishnan V. The mechanism for activation of GTP hydrolysis on the ribosome. Science. 2010, Nov 5; 330(6005):835-8. PMID: 21051640

Schmeing TM*, Voorhees RM*, Kelley AC, Gao YG, Murphy FV, Weir JR, Ramakrishnan V. The crystal structure of the ribosome bound to EF-Tu and tRNA. Science. 2009, Oct 30; 326(5953):688-94. PMID: 19833920

Schmeing TM, Ramakrishnan, V. What recent ribosome structures have revealed about the mechanism of translation. Nature. 2009, Oct 29; 461(7268):1234-1242. PMID: 19838167

Passmore LA, Schmeing TM, Maag D, Applefield A, Acker MG, Algire MA , Lorsch JR,  and Ramakrishnan V. The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome. Mol Cell. 2007 Apr 13;26(1):41-50. PMID: 17434125

Schmeing TM, Huang KS, Strobel SA, Steitz TA. An induced fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA. Nature. 2005 Nov 24;438(7067):520-4. PMID: 16306996

Schmeing TM, Huang KS, Kitchen DE, Strobel SA, Steitz TA. Structural insights into the roles of the 2' hydroxyl of the peptidyl-tRNA and water in the peptidyl transferase reaction. Mol Cell. 2005 Nov 11;20(3):437-48. PMID: 16285925

Schmeing TM, Moore PB, Steitz TA. Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit. RNA. 2003, Nov; 9(11):1345-52. PMID: 14561884

Hansen JL, Schmeing TM, Moore PB, Steitz TA. Structural insights into peptide bond formation. Proc Natl Acad Sci USA. 2002 Sep 3;99(18):11670-5. PMID: 12185246

Schmeing TM, Seila AC, Hansen JL, Freeborn B, Soukup JK, Scaringe SA, Strobel SA, Moore PB, Steitz TA. A pre - translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits. Nat Struct Biol. 2002 Mar;9(3):225-30. PMID: 11828326

Hansen JL, Schmeing TM, Klein DJ, Ippolito JA, Nissen P, Ban N, Moore PB, Steitz TA (2001) "Progress towards an understanding of the structure and enzymatic mechanism of the large ribosomal subunit." Cold Spring Harbor Symposia on Quantitative Biology. 2001; 66:33-42. PMID: 12762006

Klein DJ*, Schmeing TM*, Moore PB, Steitz TA. The kink-turn: a new RNA secondary structure motif. EMBO J. 2001 Aug 1;20(15):4214-21. PMID: 11483524

Chu LL, Rutteman GR, Kong JM, Ghahremani M, Schmeing M, Misdorp W, van Garderen E, Pelletier J. Genomic organization of the canine p53 gene and its mutational status in canine mammary neoplasia. Breast Cancer Res Treat. 1998 Jul;50(1):11-25. PMID: 9802616